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The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis
Jiwon Jung1, Aram Kim2, Seung-Hoon Yang1
1Department of Biomedical Engineering, College of Life Science and Biotechnology, Dongguk University, Seoul, Korea.
International Neurourology Journal
|April 4, 2023
Summary
Functional bladder disorders like overactive bladder and interstitial cystitis impact the brain and gut. Understanding the bladder-brain-gut axis is key to diagnosing these complex conditions accurately.
Area of Science:
- Urology
- Neurogastroenterology
- Psychiatry
Background:
- Functional bladder disorders (FBDs) present complex symptoms, often leading to misdiagnosis.
- FBDs are frequently associated with mood disorders (e.g., depression, anxiety) and gastrointestinal conditions (e.g., IBS, IBD).
Purpose of the Study:
- To elucidate the pathophysiology of FBDs by exploring the interconnectedness of the bladder, brain, and gut.
- To provide a novel understanding of the overlapping clinical presentations in FBDs.
Main Methods:
- Literature review focusing on the bladder-brain axis.
- Literature review examining the bladder-gut axis.
- Analysis of the brain-gut axis's role in modulating bladder activity.
Main Results:
- Evidence links bladder disorders with mood disturbances and gastrointestinal diseases.
- The brain-gut axis significantly influences bladder function, potentially altering permeability, inflammation, and microbial balance.
- Affective disorders can impact the autonomic nervous system, affecting gut homeostasis and subsequently bladder health.
Conclusions:
- The bladder-brain-gut axis is a critical factor in the pathophysiology of FBDs.
- Understanding these complex interactions offers new diagnostic and therapeutic insights for FBDs.
- This review highlights the need to consider systemic connections in managing functional bladder disorders.
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