Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke

Sook-Lei Liew¹, Nicolas Schweighofer², James H Cole²+70

• ¹From the Laboratory of Neuro Imaging (G.B.), Imaging Genetics Center (N.J., P.M.T.), and Department of Neurology (N. Sanossian, C.J.W.), Mark and Mary Stevens Neuroimaging and Informatics Institute (S.-L.L., J.H.K., H.K., G.P.), Keck School of Medicine, University of Southern California, Los Angeles; Chan Division of Occupational Science and Occupational Therapy (S.-L.L., B.P.L., M.R.D., J.N.J., Z.W., A.A., A.H., J.A.H., J.L.M.), Division of Biokinesiology and Physical Therapy (N. Schweighofer, C.J.W., S.-L.L.), and Herman Ostrow School of Dentistry, University of Southern California, Los Angeles; Centre for Medical Image Computing (J.H.C.), Department of Computer Science, Dementia Research Centre (J.H.C.), Queen Square Institute of Neurology, University College London, United Kingdom; Brain Mapping Center (A.Z.-P.), Department of Neurology, Geffen School of Medicine, University of California, Los Angeles; Centre for Youth Mental Health (L.K.M.H., L.S.) and Melbourne School of Psychological Sciences (N.E.-B.), University of Melbourne, Parkville, Victoria, Australia; Institute for Translational Psychiatry (T.H.), University of Münster, Germany; Department of Physical Therapy and Djavad Mowafaghian Centre for Brain Health (L.A.B.), University of British Columbia, Vancouver, Canada; The Florey Institute of Neuroscience and Mental Health (A.B., K.H., M.S.K.); Eastern Cognitive Disorders Clinic (A.B.); Royal Melbourne Hospital (A.B.), Victoria, Australia; Department of Neurology (C.M.B.) and Facility for Education and Research in Neuroscience (K.P.R.), Emory University, Atlanta, GA; Centre for Brain Research and Department of Exercise Sciences (W.D.B.), University of Auckland, New Zealand; Department of Health Sciences (J.M.C.), University of North Carolina at Chapel Hill; Department of Basic and Clinical Sciences (C.C.C.), Center for Neuroscience and Integrative Brain Research (CENIBRE) (C.C.C.), University of Nicosia Medical School, Cyprus; Laboratory of Neuropsychiatry (V.C., F.P.), IRCCS Santa Lucia Foundation, Rome, Italy; Hospital das Clínicas (A.B.C.), São Paulo University; Hospital Israelita Albert Einstein (A.B.C.), São Paulo, Brazil; Department of Psychiatry and Clinical Psychobiology (R.D.-A.), Universitat de Barcelona, Spain; Center for Neurotechnology and Neurorecovery (J.A.D., D.J.L.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Functional Imaging Unit (M.D.), Diagnostic and Neuroradiology and Functional Imaging Unit (M.L.), Diagnostic Radiology and Neuroradiology, Universitymedicine Greifswald, Germany; Departments of Neurology (A.N.D.) and Physical Medicine & Rehabilitation (K.A.W.), Dell Medical School at The University of Texas Austin; Department of Neurology (W.F.), Duke University School of Medicine, Durham, NC; Clinical Language and Cognition (CLC) Lab (F.G.), Department of Brain Sciences, Imperial College London, United Kingdom; Department of Health Sciences & Research (C.M.G., S.A.K.), Medical University of South Carolina, Charleston; Cancer Biology (C.A.H.), Wake Forest School of Medicine, Winston Salem, NC; Innovation, Implementation and Clinical Translation (IIMPACT) in Health (B.H.), Allied Health and Human Performance, University of South Australia, Adelaide; Ralph H. Johnson VA Medical Center (S.A.K., N.J.S.), Charleston, SC; Department of Radiology (A.K., E.R.O.), Weill Cornell Medicine, New York, NY; Department of Radiology (J.L., C.Y.), Tianjin Medical University General Hospital, China; Hurvitz Brain Sciences Program (B.J.M.), Centre for Brain Resilience & Recovery and Canadian Partnership for Stroke Recovery (A.D.R.), Sunnybrook Research Institute, Toronto, Ontario, Canada; Computational Radiology Artificial Intelligence Unit (B.J.M.) and Norwegian Centre for Mental Disorders Research (NORMENT) (L.T.W.), Department of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Clinical Psychology and Psychobiology (M.M.), and Institut de Neurociències (M.M.), University of Barcelona; Institut de Recerca Pediàtrica (M.M.), Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain; Jefferson Integrated MRI Center (F.B.M.), Department of Radiology, Thomas Jefferson University, Philadelphia, PA; Cedars-Sinai (P.R.), Los Angeles, CA; California Rehabilitation Institute (P.R., S.C.C.), Los Angeles; Department of Kinesiology and Health Sciences (A.D.R.), University of Waterloo, Ontario, Canada; Department of Neurology (H.M.S., M.T.), NYU Langone, New York; Department of Rehabilitation Sciences (N.J.S.), and Department of Health Sciences and Research (N.J.S.), Medical University of South Carolina, Charleston; Department of Psychiatry and Neurosciences (S.R.S.), Clinical Neurotechnology Laboratory, Charité-Universitätsmedizin Berlin, Germany; Laboratory of Neuropsychiatry (G.S.), IRCCS Santa Lucia Foundation, Rome, Italy; Division of Neuropsychiatry (G.S.), Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX; Department of Medicine (C.M.S.), University of Auckland, New Zealand; Department of Psychiatry (W.K.T.), Faculty of Medicine, The Chinese University of Hong Kong; Department of Physical Therapy and Neuroscience (G.T.T.), University of the Sciences, Philadelphia, PA; Department of Clinical and Behavioral Neurology (D.V.), IRCCS Santa Lucia Foundation, Rome, Italy; UCL Queen Square Institute of Neurology (N.S.W.), London, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Department of Neurology & RNEL (G.F.W.), University of Pittsburgh; GRECC/HERL (G.F.W.), VA Pittsburgh Healthcare System, PA; Department of Rehabilitation Medicine Division of Physical Therapy (M.R.B., S.L.W.), Department of Rehabilitation Medicine, Division of Geriatric Medicine (S.L.W.), Department of Medicine, and Department of Cell Biology (S.L.W.), Emory University School of Medicine; Center for Visual and Neurocognitive Rehabilitation (S.L.W.), Atlanta VA Health Care System, GA; and Department of Neurology (S.C.C.), University of California, Los Angeles. Giuseppe Barisano is currently at the department of Neurosurgery, Stanford Medicine, Stanford University, CA; Kathryn Hayward is currently at the departments of Physiotherapy and Medicine (RMH), University of Melbourne, Parkville, Victoria, Australia; and Gregory T. Thielman is currently at Physical Therapy and Neuroscience, School of Health Professions, Saint Joseph's University, Philadelphia, PA. sliew@chan.usc.edu.+1