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Related Concept Videos

Infection01:20

Infection

8.4K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
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Visualisation of Host-Pathogen Communication.

Amy Dumigan1, Ricardo Calderon Gonzalez2, Brenda Morris2

  • 1Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK. a.dumigan@qub.ac.uk.

Advances in Experimental Medicine and Biology
|April 4, 2023
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Summary

Visualisation techniques are crucial for understanding host-pathogen interactions and developing new treatments for infectious diseases, especially concerning antimicrobial-resistant bacteria.

Keywords:
BacteriaCytometryHost–pathogen interactionsImmune system

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Area of Science:

  • Biomedical research
  • Infectious disease biology
  • Immunology

Background:

  • Medical advances rely heavily on visualization techniques for disease diagnosis and treatment.
  • Despite progress, understanding human physiology, disease pathology, and infection biology remains incomplete.
  • Antimicrobial-resistant bacteria pose a significant global health threat, necessitating research into pathogenesis.

Purpose of the Study:

  • To review visualization techniques used in biomedical research, focusing on host-pathogen interactions.
  • To highlight methods for studying bacterial pathogenesis and host immune responses.
  • To explore novel therapeutic strategies in the context of a potential post-antibiotic era.

Main Methods:

  • Overview of common visualization techniques including staining, in situ hybridization, microscopy, and western blotting.
  • Discussion of advanced methods like image flow cytometry and mass spectrometry.
  • Exploration of in vitro and ex vivo modeling for pathogenicity studies.

Main Results:

  • Visualization techniques are essential for studying host-pathogen communication.
  • These methods aid in delineating pathogenicity mechanisms in various disease models.
  • Understanding these interactions is key to developing non-antibiotic therapeutics.

Conclusions:

  • Advanced visualization tools are vital for advancing biomedical research and combating infectious diseases.
  • Studying host-pathogen interactions is critical for developing novel therapeutic approaches.
  • Addressing the threat of antimicrobial resistance requires continued innovation in research methodologies.