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P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?

Dominik Klaver1, Martin Thurnher2

  • 1Immunotherapy Unit, Department of Urology, Medical University of Innsbruck, Innrain 66a, 6020, Innsbruck, Austria.

Purinergic Signalling
|April 4, 2023
PubMed

Insights

The human ATP receptor P2Y11, crucial for immune cell function, has unclear signaling pathways. This review explores its crosstalk with the IL-1 receptor in macrophages, revealing roles in inflammation and angiogenesis.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Pharmacology

Background:

  • The P2Y11 receptor, a human ATP receptor, couples to Gq and Gs proteins, but its downstream signaling remains poorly understood.
  • Limited availability of research tools and animal models has hindered the study of P2Y11 expression and function.
  • P2Y11 is implicated in regulating inflammation, cell migration, and mitochondrial activity, particularly in immune cells.

Purpose of the Study:

  • To review current understanding of P2Y11 receptor signaling pathways.
  • To summarize findings from transcriptomic and secretomic analyses of P2Y11.
  • To explore the crosstalk between P2Y11 and the IL-1 receptor in human M2 macrophages.

Main Methods:

  • Transcriptomic and secretomic analyses of ectopic and native P2Y11 receptors.
  • Review of existing literature on P2Y11 function in immune cells.
  • Analysis of P2Y11 upregulation during macrophage development.

Main Results:

  • P2Y11 is upregulated during macrophage development.
  • P2Y11 signaling activates pathways through the IL-1 receptor.
  • Transcriptomic and secretomic data provide insights into P2Y11 function.

Conclusions:

  • P2Y11 plays a significant role in regulating inflammatory and migratory processes.
  • Crosstalk between P2Y11 and IL-1 receptor influences anti-inflammatory and pro-angiogenic activities in M2 macrophages.
  • Further research into P2Y11 signaling is warranted to understand its therapeutic potential.
Keywords:
HomeostasisInflammationMacrophage polarizationNanoString

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