Related Experiment Video
Updated: Aug 4, 2025
19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
18.6K
HIV and hypertension epidemiology.
Ileana De Anda-Duran1, Alexander D Kimbrough1, Lydia A Bazzano1,2
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine.
Current Opinion in Cardiology
|April 5, 2023
Summary
Hypertension in people living with HIV (PLWH) is complex, influenced by HIV and its treatments. Management aligns with general guidelines but requires careful consideration of antiretroviral therapy drug interactions.
Area of Science:
- Cardiovascular Health
- Infectious Diseases
- Public Health
Background:
- Growing prevalence of HIV as a chronic condition.
- Increasing incidence of hypertension in the general population.
- The critical intersection of HIV and hypertension management.
Approach:
- Review of current literature on hypertension burden in people living with HIV (PLWH).
- Analysis of the complex pathogenesis linking HIV, inflammation, antiretroviral therapy (ART), and comorbidities.
- Evaluation of existing and emerging treatment recommendations.
Key Points:
- HIV contributes to hypertension through chronic inflammation, ART, and comorbidities like renal disease and insulin resistance.
- Standard non-pharmacological interventions (lifestyle changes) are recommended.
- Pharmacological treatment is similar to HIV-uninfected individuals, with careful attention to ART drug interactions.
Conclusions:
- Understanding the multifaceted pathogenesis of hypertension in PLWH is crucial for tailored clinical management.
- Further research is essential to elucidate hypertension's pathways and effects in the context of HIV.
- Integrated management strategies are needed for optimal cardiovascular health in PLWH.
More Related Videos
Related Concept Videos
01:29Hypertension II: Pathophysiology
27
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
27
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
36
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
36
01:28Hypertension I: Introduction
34
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
34
01:26Sexually Transmitted Infections
375
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
375
01:18Hypertension and Regulation of Blood Pressure
2.2K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.2K
01:10Retrovirus Life Cycles
46.4K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.4K