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Related Experiment Videos

Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma).

L E Kahl, T A Medsger, I Klein

    The Journal of Rheumatology
    |February 1, 1986
    PubMed
    Summary
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    Clinical and experimental rheumatology·2014

    Thyroid dysfunction is common in systemic sclerosis patients, frequently occurring without obvious symptoms or autoimmune markers. Early thyroid screening is crucial for managing this autoimmune connective tissue disease.

    Area of Science:

    • Endocrinology
    • Rheumatology
    • Immunology

    Background:

    • Systemic sclerosis is an autoimmune connective tissue disease with potential multi-organ involvement.
    • Thyroid dysfunction can be a complication of systemic sclerosis, but is often subclinical.

    Purpose of the Study:

    • To evaluate the prevalence and clinical characteristics of thyroid disease in patients with systemic sclerosis.
    • To assess thyroid function using standard tests and thyrotropin-releasing hormone (TRH) stimulation.

    Main Methods:

    • Seventy-seven ambulatory, clinically euthyroid patients with systemic sclerosis were assessed.
    • Thyroid function tests and TRH response tests were performed.
    • Patients were categorized based on thyroid function and TRH test results.

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    Main Results:

    • Twenty-three percent of patients exhibited abnormal thyroid function, including 10% with chemical hypothyroidism and 13% with an exaggerated TRH response.
    • Antithyroid antibodies were found in 50% of the hypothyroid group.
    • No significant differences in disease extent, organ involvement, or hypothyroidism symptoms were observed between patient groups.

    Conclusions:

    • Abnormal thyroid function is frequent in systemic sclerosis and often clinically unsuspected.
    • Thyroid dysfunction may occur even without serological markers of autoimmune thyroid disease.
    • Routine thyroid function monitoring is recommended for systemic sclerosis patients.