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Related Experiment Videos

Histamine levels in human synovial fluid.

D B Frewin, L G Cleland, J R Jonsson

    The Journal of Rheumatology
    |February 1, 1986
    PubMed
    Summary

    Histamine levels are elevated in the plasma and synovial fluid (SF) of patients with arthritis. Increased histamine in SF suggests its role in the development of joint effusions in inflammatory joint disease.

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    Area of Science:

    • Rheumatology
    • Immunology
    • Biochemistry

    Background:

    • Arthritis involves joint inflammation and fluid accumulation.
    • Histamine is a biogenic amine with roles in inflammation.

    Purpose of the Study:

    • To quantify histamine levels in arthritic patients.
    • To investigate the relationship between histamine and joint effusions.

    Main Methods:

    • Radioenzymatic assay was used to measure histamine.
    • Histamine was measured in plasma and synovial fluid (SF).
    • Patients with various arthritides were studied and compared to controls.

    Main Results:

    • Plasma histamine levels were higher in arthritis patients than controls.
    • Synovial fluid (SF) histamine levels exceeded plasma levels in all patients.
    • Elevated histamine was observed across various arthritides.

    Conclusions:

    • Histamine is significantly elevated in the plasma and SF of patients with inflammatory joint disease.
    • Synovial histamine may play a crucial role in the formation of joint effusions.
    • Further research into histamine's role in synovium is warranted.

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