Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Facilitated Diffusion01:16

Facilitated Diffusion

527
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
527
Facilitated Transport01:19

Facilitated Transport

128.6K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
128.6K
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

541
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
541
Secondary Active Transport01:32

Secondary Active Transport

7.2K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
7.2K
Diffusion01:12

Diffusion

194.3K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
194.3K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

714
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
714

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermochemical Micro-Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Hydrophobic Promoter-Enhanced Tandem Catalysis for Alkene Epoxidation With H<sub>2</sub> and O<sub>2</sub>.

Angewandte Chemie (International ed. in English)·2026
Same author

Conjugation-induced π-electron modulation in pyridazine-integrated covalent organic frameworks for SO<sub>2</sub> capture and upcycling.

Nature communications·2026
Same author

Confinement-Driven Anomalous Behaviors for Diffusion in Zeolites: Mechanisms and Beyond.

Accounts of chemical research·2026
Same author

Characterization of high-purity <i>Aeromonas salmonicida</i> extracellular vesicles and their inhibitory activity against <i>Pseudomonas fluorescens</i> biofilm formation.

Food science and biotechnology·2026
Same author

Porous bismuth-based liquid metal as multifunctional material.

iScience·2026

Related Experiment Video

Updated: Aug 4, 2025

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
08:26

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route

Published on: April 3, 2016

13.4K

Loading-Driven Diffusion Pathway Selectivity in Zeolites with Continuum Intersecting Channels.

Wei Rao1,2, Xiaomin Tang2, Kaifeng Lin1

  • 1School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, P. R. China.

The Journal of Physical Chemistry Letters
|April 5, 2023
PubMed
Summary

Unique zeolites with continuum intersecting channels enable tunable diffusion pathways. Molecular loading controls whether diffusion occurs in smaller or larger channels, impacting heterogeneous catalysis.

More Related Videos

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
08:06

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

8.6K
Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
09:14

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

9.0K

Related Experiment Videos

Last Updated: Aug 4, 2025

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
08:26

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route

Published on: April 3, 2016

13.4K
Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
08:06

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

8.6K
Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
09:14

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

9.0K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Catalysis

Background:

  • Diffusion in zeolites is crucial for heterogeneous catalysis.
  • Zeolites with intersecting channels (BEC, POS, SOV) exhibit unique diffusion behaviors.

Purpose of the Study:

  • Investigate diffusion processes in zeolites with "continuum intersecting channels".
  • Understand how molecular loading influences diffusion pathways and rates.
  • Explore potential applications in product and byproduct separation during catalysis.

Main Methods:

  • Computational modeling and simulation of diffusion in zeolite structures.
  • Analysis of adsorption sites and diffusion barriers at varying molecular loadings.
  • Characterization of zeolite framework properties (BEC, POS, SOV).

Main Results:

  • Zeolites with continuum intersecting channels show spontaneous switching of diffusion pathways based on loading.
  • At low loading, diffusion favors smaller channels due to adsorption sites and reorientation.
  • At high loading, diffusion shifts to larger channels due to lower energy barriers within continuum intersections.

Conclusions:

  • Molecular loading is a key factor in controlling diffusion pathways in these unique zeolites.
  • The ability to tune diffusion pathways offers new strategies for optimizing heterogeneous catalysis.
  • This research provides insights for designing advanced zeolites for selective separation processes.