Continuous subcutaneous rhPTH infusion for managing difficult chronic hypoparathyroidism. A systematic review

Area of Science:

• Endocrinology
• Metabolic Diseases
• Pharmacology

Background:

• Standard treatment for chronic hypoparathyroidism involves long-term oral calcium and vitamin D supplementation.
• Exogenous parathyroid hormone (PTH) is available but often provides suboptimal disease control for many patients.
• The use of infusion pumps in diabetes management inspired the hypothesis that continuous subcutaneous PTH infusion could improve hypoparathyroidism control.

Conclusions:

• Continuous subcutaneous PTH infusion appears to be an effective, safe, and feasible treatment option for chronic hypoparathyroidism refractory to standard therapy.
• Careful patient selection is crucial for successful implementation.
• A skilled healthcare team, appropriate local setting assessment, and collaboration with pump suppliers are essential for optimal outcomes.