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Published on: April 5, 2024
Phacoemulsification Tip Elongation Under Standardized Resistance: An Objective Measure of Human Crystalline Lens
Tommaso Rossi1, Mario R Romano2, Antonio Carotenuto3
1IRCCS Fondazione Bietti ONLUS, Roma, Italy.
Purpose:
To establish a correlation between phacoemulsification tip normalized driving voltage (NDV) and crystalline lens hardness and use it as an objective measure of lens hardness. The study used a phaco tip equipped with previously validated elongation control adjusting the driving voltage (DV) to produce invariant elongation regardless of resistance.
Methods:
The laboratory study measured the mean and maximum DV of the phaco tip immersed in glycerol-balanced salt solution and correlated the DV with the kinematic viscosity at 25, 50, and 75 µm tip elongation. The NDV were obtained by dividing the DV in glycerol by the DV in the balanced salt solution. The clinical arm of the study recorded DV of 20 consecutive cataract surgeries. The correlation of mean and maximum NDV to Lens Opacities Classification System (LOCS) III classification, patient's age and effective phaco time were evaluated.
Results:
The mean and maximum NDV correlated with the kinematic viscosity of the glycerol solution (P < 0.001 in all cases). Mean and maximum NDV during cataract surgery correlated with patients' age, effective phaco time, LOCS III nuclear color, and nuclear opalescence (P < 0.001 in all cases).
Conclusions:
When a feedback algorithm is running, DV variation strictly correlates with encountered resistance in glycerol solutions and real-life surgery. NDV significantly correlates with the LOCS classification. Future developments might include sensing tips that react to lens hardness in real time.
Translational Relevance:
The study correlates for the first time phaco tip DV and crystalline lens mechanical properties, establishing an objective and reliable measure of lens hardness. This may lead to smart phaco tips reacting to cataract hardness change in real time and sparing ultrasound dispersion.
