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Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze1, Adlin Pinheiro2, Serkalem Demissie2

  • 1Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA; NHLBI's Framingham Heart Study, Framingham, MA, USA.

Neurobiology of Aging
|April 5, 2023
PubMed

Insights

Inflammation is linked to enlarged perivascular spaces (PVS) in the brain, a marker of small vessel disease. Specific inflammatory biomarkers correlate with PVS burden in different brain regions, suggesting a role in disease development.

Area of Science:

  • Neurology
  • Vascular Biology
  • Biomarkers

Background:

  • Perivascular spaces (PVS) are drainage channels in the brain that can enlarge with age and disease.
  • Cerebral small vessel disease (SVD) is a major contributor to stroke and cognitive decline.
  • The relationship between systemic inflammation and PVS burden is not fully understood.

Purpose of the Study:

  • To investigate the association between various inflammatory biomarkers and PVS burden in specific brain regions.
  • To explore the role of inflammation in the pathogenesis of SVD and PVS dysfunction.

Main Methods:

  • Cross-sectional study of 3604 participants from the Framingham Heart Study, free of stroke and dementia.
  • Magnetic resonance imaging (MRI) was used to assess PVS in the basal ganglia (BG) and centrum semiovale (CSO).
  • Multivariable ordinal logistic regression analysis correlated inflammatory biomarkers with PVS burden, controlling for vascular risk factors and SVD markers.

Main Results:

  • Significant associations were found between specific inflammatory biomarkers (e.g., intercellular adhesion molecule-1, fibrinogen, osteoprotegerin, P-selectin) and BG PVS.
  • P-selectin was associated with CSO PVS.
  • Tumor necrosis factor receptor 2, osteoprotegerin, and CD40 ligand were linked to mixed topography PVS.

Conclusions:

  • Inflammation may play a role in the development of SVD and impaired PVS drainage.
  • Different inflammatory biomarkers are associated with PVS burden depending on the topographical location within the brain.
Keywords:
Basal gangliaCentrum semiovaleGlymphatic functionInflammatory biomarkersMRI visible perivascular spaces

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