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Related Experiment Video

Updated: Aug 4, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Digital light processing-bioprinted poly-NAGA-GelMA-based hydrogel lenticule for precise refractive errors

Shuo Jia1, Jirong Yang2, Aaron Dzi-Shing Lau3

  • 1Department of Ophthalmology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.

Biofabrication
|April 5, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces custom 3D-bioprinted poly-NAGA-GelMA (PNG) lenticules for refractive error correction. These bio-safe implants offer precise, individualized vision correction with excellent biocompatibility and regenerative potential.

Keywords:
corneal regeneration and replacementdigital light processing-bioprintinghydrogelrefractive errors correctionvisual acuity

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Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Regenerative Medicine

Background:

  • Refractive errors are a leading cause of global visual impairment.
  • Current treatments require improvement in personalization, precision, and safety.
  • There is a need for advanced stromal implants for refractive error correction.

Purpose of the Study:

  • To develop and evaluate pre-designed refractive lenticules using poly-NAGA-GelMA (PNG) bio-inks and digital light processing (DLP)-bioprinting.
  • To assess the optical, biomechanical, and cytocompatibility properties of PNG lenticules.
  • To investigate the *in vitro* immune response and *in vivo* performance of PNG lenticules as stromal implants.

Main Methods:

  • Digital light processing (DLP)-bioprinting of poly-NAGA-GelMA (PNG) bio-inks to create refractive lenticules with precise dimensions (10 µm).
  • Material characterization including optical, biomechanical, swelling, and hydrophilic properties.
  • Cytocompatibility testing with corneal cells (epithelial, stromal, endothelial).
  • *In vitro* immune response analysis using RNA sequencing on human peripheral blood mononuclear cells.
  • *In vivo* assessment via intrastromal keratoplasty in New Zealand white rabbits.

Main Results:

  • PNG lenticules demonstrated excellent optical and biomechanical stability, suitable swelling, and hydrophilic properties.
  • High cytocompatibility with corneal cells, showing firm adhesion, >90% viability, and maintained cell phenotype.
  • *In vitro* studies indicated PNG lenticules promote type-2 immunity, aiding regeneration and reducing inflammation.
  • *In vivo* implantation in rabbits resulted in stable optics, controlled bio-integration, and regeneration without adverse effects or complications.
  • Postoperative examinations showed no impact on intraocular pressure, corneal sensitivity, or tear production up to 1 month.

Conclusions:

  • DLP-bioprinted PNG lenticules are bio-safe and functionally effective stromal implants.
  • Customizable physical dimensions offer potential for precise, individualized refractive error correction.
  • PNG lenticules show promise as a therapeutic strategy for vision correction, promoting tissue regeneration and minimizing inflammation.