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Neutrophil, NETs and Behçet's disease: A review
Alexandre Le Joncour1, Patrice Cacoub1, Yacine Boulaftali2
1Sorbonne Université, INSERM, UMR S 959, Immunology-Immunopathology- Immunotherapy (I3), F-75005 Paris, France; Biotherapy (CIC-BTi), Hôpital Pitié-Salpêtrière, AP-HP, F-75651 Paris, France; Sorbonne Université, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal medicine and clinical immunology, DMU3ID, F-75013 Paris, France; Laboratoire d'excellence TRANSIMMUNOM, RHU iMAP, Paris, France; Centre national de référence des Maladies Autoimmunes systémiques rares, France.
Abstract:
Behçet's disease (BD) is a chronic systemic vasculitis characterized by recurrent oral and genital ulcers, skin lesions, articular, neurological, vascular and sight-threatening ocular inflammation. BD is thought to share both autoimmune and autoinflammatory disease features. BD is triggered by environmental factors such as infectious agents in genetically predisposed subjects. Neutrophils seem to play an instrumental role in BD and recent works regarding the role of neutrophils extracellular traps (NETs) provides new insight in the pathophysiology of BD and the mechanisms involved in immune thrombosis. This review provides a recent overview on the role of neutrophils and NETs in the pathogenesis of BD.
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