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An emerging generation of endocrine therapies in breast cancer: a clinical perspective

Rima Patel1, Paula Klein2, Amy Tiersten2

  • 1Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA. Rima.patel2@mountsinai.org.

NPJ Breast Cancer
|April 5, 2023
PubMed

Insights

New anti-estrogen therapies, including SERMs, SERDs, CERANs, PROTACs, and SERCAs, are emerging to treat hormone receptor-positive breast cancer and overcome endocrine resistance. Their efficacy and toxicity are being evaluated in ongoing clinical trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Endocrinology

Background:

  • Anti-estrogen therapy is crucial for treating hormone receptor (HR)-positive breast cancer.
  • Endocrine resistance is a significant challenge in breast cancer treatment.
  • Novel therapeutic strategies are needed to improve patient outcomes.

Purpose of the Study:

  • To review the recent emergence and development of novel anti-estrogen therapies.
  • To discuss agents designed to overcome endocrine resistance in HR-positive breast cancer.
  • To evaluate the efficacy, toxicity, and clinical trial status of new anti-estrogen drugs.

Main Methods:

  • Review of current literature on emerging anti-estrogen therapies.
  • Analysis of drug classes including selective estrogen receptor modulators (SERMs), selective estrogen receptor degraders (SERDs), complete estrogen receptor antagonists (CERANs), proteolysis targeting chimeric (PROTACs), and selective estrogen receptor covalent antagonists (SERCAs).
  • Examination of data from completed and ongoing clinical trials.

Main Results:

  • Several new anti-estrogen drugs are in various stages of development.
  • These novel agents target common mechanisms of endocrine resistance.
  • Efficacy, toxicity profiles, and target patient populations differ among these new drugs.

Conclusions:

  • New generations of anti-estrogen therapies show promise for HR-positive breast cancer.
  • These agents, including SERMs, SERDs, CERANs, PROTACs, and SERCAs, offer potential to overcome endocrine resistance.
  • Ongoing clinical trials will further define their role in early and advanced breast cancer treatment.

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