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Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center

Claudia Gibarti1, Pavol Murín2, Mikuláš Huňavý2

  • 1Department of Radiology, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia.

Experimental and Therapeutic Medicine
|April 6, 2023
PubMed

Insights

Regadenoson is a superior pharmacological stress agent for cardiac computed tomography perfusion imaging compared to adenosine. It offers improved hemodynamic assessment with fewer side effects in patients with suspected ischemic heart disease.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Cardiac computed tomography (CT) angiography is crucial for assessing coronary artery obstruction.
  • Dynamic myocardial perfusion imaging quantifies blood flow in the heart muscle.
  • Non-invasive diagnosis of ischemic heart disease benefits from advanced imaging techniques.

Purpose of the Study:

  • To compare the efficacy and safety of regadenoson versus adenosine for pharmacological stress in cardiac CT perfusion imaging.
  • To evaluate hemodynamic parameters and adverse effects associated with each stress agent.

Main Methods:

  • 46 patients with suspected ischemic heart disease underwent pharmacologically induced myocardial stress using either adenosine or regadenoson.
  • Dynamic CT perfusion imaging was performed to assess myocardial blood flow.
  • Hemodynamic parameters and adverse events were systematically recorded.

Main Results:

  • Regadenoson induced a greater increase in heart rate compared to adenosine.
  • Regadenoson's effect on myocardial blood flow was independent of body mass index.
  • Regadenoson was associated with a lower incidence of mild adverse effects.

Conclusions:

  • Regadenoson demonstrates a favorable profile for pharmacological stress in cardiac CT perfusion.
  • Clinical evidence supports the wider use of regadenoson over adenosine for improved patient outcomes and diagnostic accuracy.

Keywords:
angiographyheartischemic heart diseasemyocardial blood flowperfusion

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