[Pharmacokinetics of cefoperazone concentration in human lung tissue]

In 11 patients, the concentration of cefoperazone (CPZ) in the lung tissue were studied after a 2 g intravenous bolus injection. Samples of lung tissue and blood were taken during surgery at 15, 30, 60, 120, 180, 240, and 300 minutes after administration of CPZ. All samples were assayed by the paper disc method using Micrococcus luteus ATCC 9341 as the indicator strain. All assay results of lung tissue were corrected for the amount of blood contained in the tissue samples by the hemoglobin content in the homogenate of lung tissue. The CPZ levels in the lung tissue were 116.2 micrograms/g at 15 min., 94.1 micrograms/g at 30 min., 74.6 micrograms/g at 60 min., 67.9 micrograms/g at 120 min., 54.6 micrograms/g at 180 min., 29.2 micrograms/g at 240 min. and 22.7 micrograms/g at 300 min. after administration, respectively. These values were higher than MIC90 values of CPZ for Pseudomonas aeruginosa, Streptococcus pneumoniae, Haemophilus influenzae and Enterobacteriaceae. The level of CPZ in the lung tissue was higher than 50% of the level in the serum until 180 minutes after administration of CPZ.