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Updated: Aug 4, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

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The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases

Anna Kopczak1, Michael S Stringer2, Hilde van den Brink3

  • 1Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.

European Stroke Journal
|April 6, 2023
PubMed

Insights

This study investigated if different blood pressure medications affect brain microvascular function in cerebral small vessel diseases (SVDs). Results will clarify optimal antihypertensive strategies for SVD patients.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a key modifiable risk factor for cerebral small vessel diseases (SVDs).
  • The differential impact of various antihypertensive drug classes on microvascular function in SVD patients remains unclear.

Purpose of the Study:

  • To compare the effects of amlodipine, losartan, and atenolol on microvascular function in patients with symptomatic SVDs.
  • To assess if amlodipine or losartan offer superior microvascular benefits compared to atenolol.

Main Methods:

  • The study employed a prospective, open-label, randomized crossover trial (TREAT-SVDs) with blinded endpoint assessment.
  • Patients with symptomatic SVDs (sporadic or CADASIL) received amlodipine, losartan, and atenolol monotherapy in random order.
  • Cerebrovascular reactivity (CVR) via MRI was the primary outcome, with blood pressure (BP) and BP variability (BPv) as secondary outcomes.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • The TREAT-SVDs trial aims to elucidate how distinct antihypertensive medications influence CVR, BP, and BPv in individuals with symptomatic sporadic and hereditary SVDs.
  • Findings are expected to inform clinical decisions regarding the management of hypertension in SVD patients.
Abstract

Keywords:
CADASILSmall vessel diseasesamlodipineantihypertensive drug classesblood pressure variabilitycerebrovascular reactivitylacunar strokemagnetic resonance imagingrandomised clinical trialvascular cognitive impairment

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