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CFD analysis of the hyper-viscous effects on blood flow across abdominal aortic aneurysm in COVID patients:
Shankar Narayan S1,2, Anuradha Bhattacharjee2, Sunanda Saha3
1Department of Mathematics and Statistics, Ramaiah University of Applied Sciences, Bengaluru, India.
Insights
COVID-19 infection increases blood viscosity, potentially worsening abdominal aortic aneurysms. This study models hyperviscous blood flow in aneurysms, revealing increased wall stress that may accelerate enlargement or rupture.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Fluid Mechanics
Background:
- COVID-19 is linked to elevated blood viscosity due to cellular changes.
- Blood hyperviscosity significantly impacts hemodynamics, particularly in arterial pathologies like aneurysms.
- Abdominal aortic aneurysms are a prevalent and often fatal condition.
Purpose of the Study:
- To investigate the hemodynamic effects of COVID-19-induced hyperviscosity on abdominal aortic aneurysms.
- To analyze blood flow patterns in patient-specific aneurysms considering elastic vessel walls.
- To evaluate the influence of elevated blood viscosity on aneurysm progression and rupture risk.
Main Methods:
- Utilized a patient-specific computational fluid dynamics (CFD) model.
- Employed the arbitrary Lagrangian-Eulerian (ALE) approach to handle fluid-structure interaction.
- Solved coupled fluid and solid mechanics equations using a Finite Element Method (FEM) solver.
Main Results:
- Simulations demonstrated increased wall shear stress in aneurysms with hyperviscous blood flow.
- The elastic nature of the aortic wall was incorporated into the flow analysis.
- Findings align with clinical observations of detrimental effects of blood hyperviscosity.
Conclusions:
- Elevated blood viscosity in COVID-19 patients can significantly increase stress on aneurysm walls.
- This increased stress may accelerate the expansion of abdominal aortic aneurysms.
- The study highlights the critical role of blood rheology in aneurysm pathophysiology and rupture risk.
Abstract:
Recent research has shown that individuals suffering from COVID-19 are accommodating an elevated level of blood viscosity due to the morphological changes in blood cells. As viscosity is a major flow parameter influencing the flow across a stenosis or an aneurysm, the examination of the significance of hyperviscosity in COVID patients is imperative in arterial pathologies. In this research, we have considered a patient-specific case in which the aneurysm is located along the abdominal aortal walls. Recent research on the side effects of COVID-19 voiced out the various effects on the circulatory system of humans. Also, as abdominal aneurysms exist very often among individuals, causing the death of 150-200 million every year, the hyper-viscous effects of blood on the flow across the diseased aorta are explored by considering the elevated viscosity levels. In vitro explorations contribute considerably to the clinical methods and treatments to be regarded. The objective of the present inquest is to research the flow field in aneurysmatic-COVID-affected patients considering the elastic nature of vessel walls, using the arbitrary Lagrangian-Eulerian approach. The study supports the various clinical findings that voiced the detrimental effects associated with blood hyperviscosity. The simulation results obtained, by solving the fluid mechanics' equations coupled with the solid mechanics' equations, employing a FEM solver suggest that the elevated stress imparted by the hyper-viscous flows on the walls of the aneurysmal aorta can trigger the fastening of the aneurysmal sac enlargement or rupture.
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