Related Experiment Video

Updated: Aug 4, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.6K

Bumetanide, a Diuretic That Can Help Children with Autism Spectrum Disorder

Esraa Shaker1, Osama El Agami1, Abeer Salamah1

  • 1Department of Pediatrics, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.

CNS & Neurological Disorders Drug Targets
|April 6, 2023
PubMed

Insights

Bumetanide shows promise in treating core symptoms of Autism Spectrum Disorder (ASD). This diuretic improved ASD symptoms in children with minimal side effects, suggesting a potential new therapeutic option.

Area of Science:

  • Neurodevelopmental Disorders
  • GABAergic Signaling
  • Pharmacological Interventions

Background:

  • Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental disorder with unknown pathogenesis.
  • Current treatments for core ASD symptoms are limited.
  • Altered GABAergic signals are implicated in ASD, and bumetanide affects these pathways.

Purpose of the Study:

  • To evaluate the safety and efficacy of bumetanide for treating core symptoms in children with ASD.

Main Methods:

  • A 6-month, double-blind, randomized, controlled study involving 80 children (3-12 years) with ASD.
  • Participants were assessed using the Childhood Autism Rating Scale (CARS) at baseline and at 1, 3, and 6 months.
  • Group 1 received bumetanide, while Group 2 received a placebo.

Main Results:

  • Bumetanide significantly improved core ASD symptoms compared to placebo after 6 months (p<0.001).
  • Improvements were observed in CARS scores and most sub-items.
  • Adverse effects associated with bumetanide were minimal and tolerable.

Conclusions:

  • Bumetanide demonstrates a significant role in treating the core symptoms of ASD.
  • The drug offers a potentially effective and safe therapeutic option for children with ASD.
Abstract

Keywords:
ASD (autism spectrum disorder)CARS (childhood autism rating scale)CCC (Cation-chloride Cotransporters)FDA.GABA (Gamma-amino-butyric acid)NKCC1bumetanide

More Related Videos

Eye Tracking Young Children with Autism09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

45.7K
Pentylenetetrazole-Induced Kindling Mouse Model07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.3K

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
177
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
130
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
238
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
782
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
321
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
825