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Modification of cisplatin toxicity by antioxidants
Japanese Journal of Pharmacology
|February 1, 1986
Summary
Free radical scavengers like alpha-tocopherol and N-N'-diphenyl-p-phenylenediamine may protect against cisplatin's kidney toxicity. This suggests free radicals contribute to the chemotherapy drug's damaging effects.
Area of Science:
- Oncology
- Toxicology
- Biochemistry
Background:
- cis-Diamminedichloroplatinum II (cisplatin) is a crucial chemotherapy drug.
- Nephrotoxicity is a significant limitation of cisplatin treatment.
- The exact mechanism of cisplatin-induced nephrotoxicity remains unclear.
Purpose of the Study:
- To investigate the potential role of free radicals in cisplatin-induced nephrotoxicity.
- To evaluate the protective effects of radical scavengers against cisplatin toxicity.
Main Methods:
- cisplatin was administered to rats.
- Body weight and blood urea nitrogen (BUN) levels were monitored.
- Rats were pre-treated with radical scavengers: alpha-tocopherol and N-N -diphenyl-p-phenylenediamine.
Main Results:
- cisplatin administration led to decreased body weight and increased BUN.
- Pre-treatment with alpha-tocopherol mitigated these cisplatin-induced effects.
- N-N -diphenyl-p-phenylenediamine also attenuated the increase in BUN.
Conclusions:
- The findings suggest that free radical damage may underlie cisplatin's nephrotoxicity.
- Radical scavengers show potential in reducing cisplatin-induced kidney damage.