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SAPHO syndrome complicated with relapsing polychondritis: A case report
Fengjiao Cao1, Xiujuan Hou1, Tianlun Kang1
1Department of Rheumatology, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, China.
International Journal of Rheumatic Diseases
|April 6, 2023
Summary
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory condition. This report details a case of relapsing polychondritis (RP) developing in a SAPHO patient, with symptoms improving after tofacitinib treatment.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic autoinflammatory disease primarily affecting osteoarticular and cutaneous systems.
- Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by episodic inflammation and degeneration of cartilaginous tissues.
Observation:
- This report describes a unique case of a patient diagnosed with SAPHO syndrome who subsequently developed auricularitis, a manifestation of RP, ten years after their initial SAPHO diagnosis.
- The auricularitis presented as a significant clinical complication in the context of pre-existing SAPHO syndrome.
Findings:
- The co-occurrence of RP, specifically auricularitis, in a patient with established SAPHO syndrome is a rare clinical observation.
- Treatment with tofacitinib demonstrated efficacy in alleviating the symptoms associated with the auricularitis in this SAPHO patient.
Implications:
- This case highlights the potential for SAPHO syndrome patients to develop other rare inflammatory or autoimmune conditions, such as RP.
- The successful use of tofacitinib suggests a potential therapeutic option for managing RP manifestations in patients with co-existing SAPHO syndrome.
- Further research is warranted to explore the potential links and overlapping mechanisms between SAPHO syndrome and RP.
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