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Updated: Aug 4, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

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Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance

Huiran Yue1,2, Xin Lu1,2

  • 1Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.

Acta Biochimica Et Biophysica Sinica
|April 6, 2023
PubMed

Insights

Antiangiogenic therapies show limited success in ovarian cancer (OC) due to resistance. Targeting metabolic reprogramming in the tumor microenvironment (TME) offers a promising strategy to overcome this resistance and improve patient outcomes.

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Antiangiogenic therapies, like bevacizumab, provide modest survival benefits for ovarian cancer (OC) patients.
  • Resistance to antiangiogenic therapy develops due to compensatory proangiogenic pathways and alternative vascularization.
  • High OC mortality necessitates understanding antiangiogenic resistance mechanisms for new treatments.

Approach:

  • This review explores the metabolic crosstalk between OC and the TME.
  • It highlights regulatory mechanisms driving antiangiogenic resistance.
  • The focus is on how metabolic reprogramming influences tumor aggressiveness and angiogenesis.

Key Points:

  • Metabolic reprogramming in the TME is crucial for tumor aggressiveness and angiogenesis.
  • Understanding the metabolic interplay is key to overcoming resistance.
  • Targeting these metabolic pathways presents a novel therapeutic avenue.

Conclusions:

  • Metabolic interventions can disrupt the OC-TME interactive network.
  • This disruption may overcome antiangiogenic resistance.
  • Metabolic therapies hold promise for improving clinical outcomes in OC patients.
Keywords:
antiangiogenic therapymetabolismovarian cancertumor microenvironment

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