Related Experiment Video

Updated: Aug 4, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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[Infants with an unexplained event: management of brief resolved unexplained events revised]

Tim P Kelder1,2, Adèle C Engelberts3, Meys M Cohen4

  • 1LUMC, Willem-Alexander kinderziekenhuis, Leiden.

Nederlands Tijdschrift Voor Geneeskunde
|April 6, 2023
PubMed

Insights

The new Dutch guideline for Brief Resolved Unexplained Events (BRUE) helps identify low-risk infants, reducing hospital admissions and diagnostic tests. This approach streamlines care for infants experiencing unexplained events.

Area of Science:

  • Pediatrics
  • Clinical Guidelines
  • Emergency Medicine

Context:

  • The Apparent Life Threatening Event (ALTE) guideline has been updated in the Netherlands.
  • The new guideline focuses on Brief Resolved Unexplained Events (BRUE).
  • This shift aims to refine the management of infants presenting with acute, unexplained medical events.

Purpose:

  • To introduce and explain the new Dutch pediatric guideline for Brief Resolved Unexplained Events (BRUE).
  • To differentiate BRUE from the previous Apparent Life Threatening Event (ALTE) guideline.
  • To outline the criteria for identifying low-risk infants requiring minimal intervention.

Summary:

  • The guideline identifies low-risk infants who do not require hospitalization or extensive diagnostic workups.
  • Three case studies illustrate the practical application and changes in managing infants with unexplained events under the new guideline.
  • The core principle is to reduce unnecessary admissions and diagnostic procedures for a specific cohort of infants.

Impact:

  • Expected to decrease hospital admissions for infants with BRUE.
  • Anticipates a reduction in diagnostic testing, leading to more efficient healthcare resource utilization.
  • Aims to improve the overall management strategy for pediatric unexplained events, ensuring appropriate care while minimizing over-intervention.

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