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Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
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Modulation of Host-Microbe Metabolism by Cholera Toxin
Claire M L Chapman1,2, Andrew Kapinos1,2, Fabian Rivera-Chávez1,2
1Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Infection and Immunity
|April 6, 2023
Summary
Cholera toxin (CT) promotes Vibrio cholerae transmission by altering host metabolism and activating pathogen genes. Further research is needed on microbiota roles and other toxins for new diarrheal disease therapies.
Area of Science:
- Microbiology
- Infectious Diseases
- Host-Pathogen Interactions
Background:
- Successful fecal-oral transmission of enteric pathogens requires high pathogen concentrations and competition with the gut microbiota.
- Cholera toxin (CT) from Vibrio cholerae induces diarrheal disease, crucial for pathogen transmission.
- CT's catalytic activity impacts host intestinal metabolism, aiding V. cholerae growth by nutrient acquisition.
Purpose of the Study:
- To investigate how CT-induced disease promotes V. cholerae fecal-oral transmission.
- To explore the modulation of host and pathogen metabolism by CT during infection.
- To examine the role of the intestinal microbiota in pathogen growth and transmission during toxin-induced disease.
Main Methods:
- Investigating CT's effects on host intestinal metabolism.
- Analyzing CT-induced gene expression in V. cholerae.
- Exploring the influence of the intestinal microbiota on V. cholerae growth and transmission.
Main Results:
- CT-induced disease alters host metabolism, facilitating V. cholerae growth via host-derived nutrients.
- CT-induced disease activates specific V. cholerae genes potentially involved in transmission.
- The interplay between CT, host metabolism, and microbiota in V. cholerae transmission is under active investigation.
Conclusions:
- CT-induced disease is a key factor promoting V. cholerae fecal-oral transmission.
- Modulation of host and pathogen metabolism by CT is central to this process.
- Further studies on microbiota roles and other bacterial toxins could lead to novel therapeutic strategies for diarrheal diseases.
Keywords:
Vibrio choleraecholeracholera toxindiarrheal diseaseenteric pathogensgut microbiotahost-pathogen interactionsmetabolismpathogenesistransmissionMore Related Videos
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