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Updated: Aug 4, 2025

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Cardiac Adipose Tissue Segmentation via Image-Level Annotations.

Ziyi Huang, Yu Gan, Theresa Lye

    IEEE Journal of Biomedical and Health Informatics
    |April 6, 2023
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a weakly supervised deep learning method for segmenting cardiac adipose tissue in optical coherence tomography (OCT) images. The approach uses image-level annotations, achieving performance comparable to fully supervised methods.

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    Area of Science:

    • Medical Imaging
    • Cardiovascular Research
    • Artificial Intelligence in Medicine

    Background:

    • Accurate identification of cardiac structural substrates is crucial for guiding interventional procedures and optimizing treatment for complex arrhythmias like atrial fibrillation and ventricular tachycardia.
    • Optical coherence tomography (OCT) is a real-time imaging modality valuable for visualizing cardiac tissue.
    • Current cardiac image analysis heavily relies on fully supervised learning, requiring extensive pixel-wise annotations, which are labor-intensive and time-consuming.

    Purpose of the Study:

    • To develop a novel two-stage deep learning framework for cardiac adipose tissue segmentation using only image-level annotations on OCT images.
    • To overcome the limitations of pixel-wise labeling in cardiac tissue segmentation.
    • To enable automatic tissue analysis with reduced annotation workload.

    Main Methods:

    • A two-stage deep learning framework was developed for cardiac adipose tissue segmentation.
    • The framework integrates class activation mapping with superpixel segmentation to address challenges with sparse tissue seeds.
    • Weakly supervised learning techniques were employed, utilizing image-level annotations instead of pixel-wise labels.

    Main Results:

    • The proposed weakly supervised approach demonstrated comparable performance to fully supervised methods trained on pixel-wise annotations.
    • The method effectively segments cardiac adipose tissue from human cardiac OCT images.
    • This study represents the first attempt at cardiac tissue segmentation on OCT images using weakly supervised learning.

    Conclusions:

    • Weakly supervised learning with image-level annotations is a viable and effective approach for cardiac tissue segmentation in OCT images.
    • The developed framework significantly reduces the need for laborious pixel-wise annotations.
    • This method bridges the gap between the need for automatic cardiac tissue analysis and the availability of annotated data.