Related Experiment Video

Updated: Aug 4, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

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Targeting the undruggable

Samuel F Bakhoum1,2

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.

Science (New York, N.Y.)
|April 6, 2023
PubMed

Insights

Basic biology research uncovers a novel therapeutic strategy for treating cancers characterized by chromosomal instability. This approach targets fundamental biological processes to combat these aggressive tumors.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Chromosomal instability is a hallmark of many cancers, contributing to tumor progression and treatment resistance.
  • Understanding the basic biological mechanisms underlying chromosomal instability is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To explore fundamental biological pathways that can be therapeutically targeted in chromosomally unstable cancers.
  • To identify a novel treatment strategy based on insights from basic biology.

Main Methods:

  • Investigated key molecular mechanisms involved in maintaining chromosomal stability.
  • Utilized genetic and cellular biology approaches to validate potential therapeutic targets.

Main Results:

  • Identified a specific biological pathway that, when modulated, impacts cancer cell viability in chromosomally unstable contexts.
  • Demonstrated the potential of targeting this pathway as a therapeutic strategy.

Conclusions:

  • Basic biological research can yield innovative treatments for complex diseases like cancer.
  • Targeting fundamental cellular processes offers a promising avenue for treating chromosomally unstable cancers.

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