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Influence of IL-6 rs1800795 and IL-8 rs2227306 polymorphisms on COVID-19 outcome

Amany A Ghazy1

  • 1Department of Pathology, Microbiology and Immunology Division, College of Medicine, Jouf University, Sakaka, Saudi Arabia.

Journal of Infection in Developing Countries
|April 6, 2023
PubMed

Insights

Specific genetic variations in IL-6 and IL-8 (interleukin-6 and interleukin-8) are linked to severe COVID-19 outcomes. These genetic markers, particularly the IL-6 rs1800795G and IL-8 rs2227306C alleles, may help predict disease severity.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Infectious Disease Epidemiology

Background:

  • Severe COVID-19 is characterized by an uncontrolled inflammatory response and cytokine storm.
  • Elevated levels of pro-inflammatory cytokines, such as IL-6 and IL-8, are observed in complicated COVID-19 cases.
  • Genetic polymorphisms in cytokine genes may influence their expression and contribute to COVID-19 severity.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the IL-6 and IL-8 genes and the severity of COVID-19.
  • To identify specific genetic variants that may serve as prognostic markers for severe COVID-19 outcomes.

Main Methods:

  • A case-control study involving 240 participants: 80 severe COVID-19, 80 mild COVID-19, and 80 healthy controls.
  • Genotyping of IL-6 rs1800795 (G/C) and IL-8 rs2227306 (C/T) using real-time polymerase chain reaction (PCR).
  • Statistical analysis including logistic regression to identify risk factors for severe COVID-19.

Main Results:

  • The IL-6 rs1800795GG and IL-8 rs2227306CC genotypes were significantly more frequent in severe COVID-19 patients.
  • The IL-6 rs1800795G and IL-8 rs2227306C alleles were more prevalent in severe COVID-19 cases.
  • Coexistence of IL-6 rs1800795G and IL-8 rs2227306C alleles increased the risk of severe COVID-19, while IL-6 rs1800795C and IL-8 rs2227306T alleles were associated with lower risk.
  • Old age, male gender, and specific genotypes of IL-6 and IL-8 were identified as independent risk factors for severe COVID-19.

Conclusions:

  • The IL-6 rs1800795G and IL-8 rs2227306C alleles are significantly associated with severe COVID-19 outcomes, particularly when present together.
  • These specific genetic variants may serve as valuable prognostic markers for predicting COVID-19 severity.
Abstract

Keywords:
COVID-19IL-6 rs1800795IL-8 rs2227306SNPoutcome

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