Tissue clearing to examine glioma complexity in 3 dimensions
Xinyi Yang1, Zhaoyu Ye1, Minglin Zhang1
1Clinical Biobank Center, Department of Laboratory Medicine, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Journal of Neuropathology and Experimental Neurology
|April 6, 2023
Summary
Tissue clearing techniques offer new ways to study brain tumors like gliomas. This review covers tissue clearing applications in glioma research, highlighting current limitations and future potential in oncology.
Area of Science:
- Neuroscience
- Oncology
- Biotechnology
Background:
- Tissue clearing has emerged as a powerful technique for 3D visualization of biological tissues.
- Significant advancements in neuropathology and brain imaging have been driven by tissue clearing.
- Application of tissue clearing to gliomas promises enhanced understanding of tumor biology.
Conclusions:
- Tissue clearing is a transformative technology for glioma research.
- Further technological development is needed to overcome existing limitations.
- Potential applications span from basic research to clinical diagnostics and treatment strategies.
Keywords:
3D visualizationGlioblastomaGlioma invasionGlioma stem cellTissue clearingTumor microenvironment
