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Related Experiment Video

Updated: Aug 4, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
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Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG

Philip P Vu1,2, Alex K Vaskov1,2,3, Christina Lee1

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States of America.

Journal of Neural Engineering
|April 6, 2023
PubMed
Summary

Regenerative Peripheral Nerve Interfaces (RPNIs) provide stable, high-quality signals for prosthetic control. This study shows RPNIs enable reliable, long-term upper-limb neuroprosthetic function with high accuracy.

Keywords:
myoelectric controlneuroprostheticspattern recognitionperipheral nerve regeneration

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Rehabilitation Engineering

Background:

  • Extracting high-amplitude, sustainable motor signals for upper-limb neuroprosthetic control remains challenging.
  • Clinical translation requires neural interfaces that provide consistent signals and reliable prosthetic performance.

Purpose of the Study:

  • To assess the long-term signal reliability of electrodes implanted in Regenerative Peripheral Nerve Interfaces (RPNIs) and residual muscles in humans.
  • To evaluate the potential of RPNIs as a stable bioamplifier for efferent motor action potentials for prosthetic control.

Main Methods:

  • Surgically implanted electrodes in RPNIs and residual muscles to record electromyography (EMG).
  • Assessed signal quality using signal-to-noise ratio (SNR) over extended periods.
  • Decoded finger and grasp movements using EMG signals for prosthetic control.

Main Results:

  • RPNI signal quality (SNR > 15) was maintained for up to 276 days (Participant 1) and 1054 days (Participant 2).
  • Participant 2 achieved >94% accuracy in real-time prosthetic performance for 604 days without recalibration.
  • Participant 2 demonstrated 99% accuracy in a real-world coffee task for 611 days without recalibration.

Conclusions:

  • RPNIs and implanted EMG electrodes offer a viable long-term interface for enhanced prosthetic control.
  • Demonstrated biological stability and bioamplification of motor action potentials by RPNIs.
  • Sustained high-performance prosthetic function without frequent recalibration.