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Updated: Aug 4, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

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Published on: May 21, 2018

MicroRNAs in inflammasomopathies.

Norma Saad¹, Isabelle Duroux-Richard¹, Isabelle Touitou²

¹Institute for Regenerative Medicine and Biotherapy, INSERM, U1183, University of Montpellier, Montpellier, France.

Immunology Letters

|April 6, 2023

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and immune responses. This review explores their emerging role in autoinflammatory diseases (AID), particularly inflammasomopathies, which involve innate immune system overactivation.

Keywords:

Autoinflammatory diseases Caspase-1 FMF, IL-1 Inflammasome miRNAs

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Area of Science:

Immunology
Genetics
Molecular Biology

Background:

MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
miRNAs are crucial in immune cell proliferation and activation, impacting inflammatory responses.
Dysregulated miRNA expression is observed in immune-mediated inflammatory disorders, including autoinflammatory diseases (AID).

Conclusions:

Further research into miRNA mechanisms is crucial for understanding inflammasomopathies and AID.
miRNAs represent potential therapeutic targets for immune-mediated inflammatory disorders.