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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

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Global burden of hepatitis B virus: current status, missed opportunities and a call for action

Yao-Chun Hsu1,2,3,4, Daniel Q Huang5,6, Mindie H Nguyen7,8

  • 1Center for Liver Diseases, E-Da Hospital, Kaohsiung, Taiwan. holdenhsu@gmail.com.

Nature Reviews. Gastroenterology & Hepatology
|April 6, 2023
PubMed

Insights

Chronic hepatitis B virus (HBV) infection impacts millions globally, causing liver disease and death. Despite prevention goals, underdiagnosis and under-treatment hinder progress, risking increased mortality.

Area of Science:

  • Hepatology and Viral Immunology
  • Global Public Health

Background:

  • Chronic hepatitis B virus (HBV) infection affects nearly 300 million people worldwide.
  • HBV is a leading cause of liver cirrhosis and liver cancer, contributing to hundreds of thousands of deaths annually.
  • Significant stigma is associated with HBV infection.

Purpose of the Study:

  • To review the current global burden of HBV infection.
  • To analyze projections for HBV-related deaths.
  • To identify gaps in the HBV care cascade and suggest future strategies.

Main Methods:

  • This review synthesizes data on the global prevalence, mortality, and care cascade of HBV infection.
  • It examines current vaccination coverage and treatment accessibility.
  • Future projections are based on current trends and public health interventions.

Main Results:

  • HBV infection remains a significant global health challenge with substantial and increasing mortality.
  • Key issues include underdiagnosis, underutilization of preventive measures like vaccines, and inadequate patient linkage to care and treatment.
  • Without intervention, global HBV deaths are projected to rise significantly by 2030.

Conclusions:

  • Urgent action is needed to address the substantial global burden of chronic HBV infection.
  • Improving vaccination rates, diagnosis, and access to care are critical to meet elimination goals.
  • Addressing gaps in the care cascade is essential to reduce HBV-related morbidity and mortality.

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