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CD-CODE: crowdsourcing condensate database and encyclopedia
Nadia Rostam1,2, Soumyadeep Ghosh1,2, Chi Fung Willis Chow1,2,3
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Nature Methods
|April 6, 2023
Summary
A new crowdsourcing database and encyclopedia (CD-CODE) integrates scientific knowledge on biomolecular condensates. This platform aims to accelerate research into their function, disease roles, and therapeutic potential.
Area of Science:
- Cell biology
- Biochemistry
- Bioinformatics
Background:
- Biomolecular condensates are crucial for intracellular organization.
- Interdisciplinary knowledge integration is needed to understand condensate function and composition.
Purpose of the Study:
- To develop a centralized, community-editable platform for biomolecular condensate research.
- To facilitate the integration of diverse scientific knowledge on condensates.
Main Methods:
- Developed the crowdsourcing condensate database and encyclopedia (CD-CODE) website.
- Created a literature-based database of biomolecular condensates.
- Incorporated an encyclopedia of relevant scientific terms.
- Implemented a crowdsourcing web application for community contributions.
Main Results:
- CD-CODE is a publicly accessible, community-editable platform.
- The platform integrates a database, encyclopedia, and crowdsourcing tools.
- It serves as a central resource for biomolecular condensate information.
Conclusions:
- CD-CODE will accelerate the discovery and validation of biomolecular condensates.
- The platform will aid in understanding condensate roles in disease.
- CD-CODE facilitates identifying condensates as potential therapeutic targets.
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