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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Elemental profiles in distant tissues during tumor progression.

Samella Salles¹, Rebecca Salles², Mauro S G Pavão³

¹Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.

|April 6, 2023

Summary

This summary is machine-generated.

Essential elements are altered in distant tissues during tumor progression, impacting cancer development. This study reveals how elements like phosphorus and copper change, offering insights into tumor microenvironment modulation.

Keywords:

Elemental distribution Essential mineral elements Lewis lung carcinoma SR-XRF Tumor progression

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Published on: June 29, 2022

Area of Science:

Oncology
Biochemistry
Metallomics

Background:

Essential elements play crucial roles in cellular processes like proliferation and migration, influencing tumor progression.
Understanding the relationship between essential elements and tumor progression is vital for cancer research.
Elemental profiles in distant tissues, which can be affected by tumor cells to promote metastasis, require further investigation.

Purpose of the Study:

To evaluate the multielemental distribution during tumor progression.
To focus on elemental changes in both primary tumor tissue and potentially affected distant tissues.

Main Methods:

In vivo tumor progression was simulated using Lewis Lung Carcinoma (LLC) cells in C57BL/6 mice.
Samples from primary tumors and distant tissues were collected over 5 weeks.
Synchrotron radiation X-ray fluorescence was used to analyze concentrations of P, S, K, Ca, Mn, Fe, Cu, and Zn.

Main Results:

Significant alterations in the distribution of P, S, K, Ca, Mn, Fe, and Cu were observed in distant tissues due to tumor presence.
An unprecedented similarity in elemental profiles was found between primary tumor tissue and non-origin tissues like the liver.
Changes in elemental concentrations were tracked over time in primary tumors, liver, and lung tissues for both control and tumor-bearing groups.

Conclusions:

The study demonstrated that primary tumors can modulate distant tissues through alterations in essential element concentrations.
Analyzing key elements provides insights into biological processes involved in cancer.
This research contributes to the field of tumoral metallomics by highlighting the role of essential elements in modulating the tumor microenvironment.