Related Experiment Video

Updated: Aug 4, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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The epigenetic function of androgen receptor in prostate cancer progression

Takahiro Sawada1,2, Yoshiaki Kanemoto1,2, Tomohiro Kurokawa1,2,3

  • 1Graduate School of Life Science and Engineering, Iryo Sosei University, Fukushima, Japan.

Frontiers in Cell and Developmental Biology
|April 7, 2023
PubMed

Insights

Androgen receptor (AR) signaling drives prostate cancer progression, even in castration-resistant states. This review explores AR

Area of Science:

  • Molecular Oncology
  • Epigenetics
  • Endocrinology

Background:

  • Androgen deprivation therapy is a standard treatment for prostate cancer.
  • Most patients develop castration (drug)-resistant prostate cancer (CRPC) despite treatment.
  • Androgen receptor (AR) remains detectable and active in CRPC.

Purpose of the Study:

  • To review the transcriptional and epigenetic regulatory roles of AR in prostate cancer.
  • To highlight clinical applications of AR-targeting agents and coregulators.
  • To emphasize AR's role in chromatin reorganization during prostate cancer progression.

Main Methods:

  • Literature review of studies on AR function, epigenetics, and prostate cancer.
  • Analysis of AR signaling pathways and their role in therapeutic resistance.
  • Discussion of AR ligands, protein co-regulators, and enhancer RNAs.

Main Results:

  • AR mediates gene regulation through ligand-dependent transcriptional activity.
  • AR influences chromatin structure, contributing to epigenetic modifications.
  • AR signaling persists in CRPC, driving tumor progression and malignancy.

Conclusions:

  • AR plays a critical role in both hormone-dependent and castration-resistant prostate cancer.
  • Epigenetic regulation by AR is a key factor in the transition to CRPC.
  • Targeting AR pathways, including its coregulators and chromatin effects, offers therapeutic potential.
Keywords:
androgenschromatin reorganizationepigeneticgenomeprostate cancer

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