Intravascular diffuse large B-cell lymphoma with acquired ichthyosis: A case report

Area of Science:

• Hematology
• Oncology
• Dermatology

Background:

• Intravascular diffuse large B-cell lymphoma (IDLBCL) is a rare non-Hodgkin lymphoma.
• It is characterized by proliferation of malignant B-cells within small blood vessels.
• IDLBCL has a poor prognosis and is often diagnosed late due to nonspecific symptoms.

Observation:

• A unique case of classic variant IDLBCL is presented in an Asian patient.
• The patient exhibited cutaneous findings, peripheral nervous system involvement, and acquired ichthyosis.
• Bone marrow biopsy was negative, underscoring diagnostic challenges.

Findings:

• Skin biopsy proved crucial for the rapid diagnosis of IDLBCL.
• The concurrent presence of acquired ichthyosis is a rare finding, reported only once previously.
• This case emphasizes the diagnostic utility of dermatological evaluation in IDLBCL.

Implications:

• Prompt dermatology consultation is vital for early IDLBCL diagnosis.
• Skin biopsy should be considered an essential diagnostic tool when IDLBCL is suspected.
• Recognizing diverse clinical presentations, including cutaneous manifestations, improves patient outcomes.