Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

13
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
13
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

617
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
617
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

21
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
21
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Pulmonary artery biopsy findings in a patient with a BMPR2 variant-associated pulmonary arterial hypertension.

Frontiers in medicine·2026
Same author

Delayed pulmonary artery-bronchial fistula following embolization of mucormycosis related pulmonary artery pseudoaneurysms.

Journal of vascular and interventional radiology : JVIR·2026
Same author

A short-trip combination method for reconstructing real-world NOx emission indicators from irregular OBD telematics of heavy-duty diesel vehicles.

Journal of hazardous materials·2026
Same author

Risk factors for post-ERCP pancreatitis and assessment of stent exchange intervals in children with chronic pancreatitis: a single-center retrospective study.

BMC pediatrics·2026
Same author

Effect of ignition timing on combustion characteristic of the elliptical rotary engine under different rotary speeds.

Scientific reports·2026
Same author

Characteristics and management of asthma from the China Asthma Data Registry Project.

ERJ open research·2026

Related Experiment Video

Updated: Aug 4, 2025

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo
10:39

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

Published on: March 8, 2018

8.4K

Diabetic endothelial microangiopathy and pulmonary dysfunction.

Lanlan Zhang1, Faming Jiang1, Yingying Xie2

  • 1Department of Respiratory and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.

Frontiers in Endocrinology
|April 7, 2023
PubMed
Summary

Type 2 diabetes mellitus (T2DM) impacts lung health, worsening respiratory diseases like COPD and COVID-19 through endothelial cell dysfunction. Understanding this link is crucial for managing T2DM comorbidities.

Keywords:
COPDCOVID-19asthmaendothelial cellstype-2 diabetes

More Related Videos

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

3.2K
Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.8K

Related Experiment Videos

Last Updated: Aug 4, 2025

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo
10:39

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

Published on: March 8, 2018

8.4K
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

3.2K
Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.8K

Area of Science:

  • Endocrinology and Pulmonology
  • Metabolic and Inflammatory Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) is a global health crisis affecting multiple organs.
  • T2DM complications primarily stem from macrovascular and microvascular damage.
  • Emerging evidence highlights the lung as a significant target organ in T2DM.

Purpose of the Study:

  • To review the association between T2DM-induced endothelial cell dysfunction and respiratory diseases.
  • To explore the shared pathogenesis between T2DM and inflammatory lung conditions.

Main Methods:

  • Literature review of recent research on T2DM and respiratory diseases.
  • Analysis of studies focusing on endothelial dysfunction in T2DM patients with lung conditions.

Main Results:

  • T2DM is a significant comorbidity influencing the progression of various respiratory disorders.
  • Shared pathways involving metabolic derangement and endothelial microangiopathy link T2DM and lung diseases.
  • Specific respiratory conditions discussed include COVID-19, asthma, COPD, and IPF.

Conclusions:

  • Endothelial cell dysfunction in T2DM plays a critical role in the development and severity of concomitant respiratory diseases.
  • Further research into the shared mechanisms can inform integrated treatment strategies for T2DM and lung conditions.