A bibliometrics analysis and visualization study of TRPV1 channel

Area of Science:

• Neuroscience
• Molecular Biology
• Pharmacology

Background:

• Transient Receptor Potential Vanilloid 1 (TRPV1) identified in the late 1990s, acts as a key human pain and heat sensor.
• Despite extensive research on its structure and function, the precise mechanism of this ion channel remains elusive.
• TRPV1's widespread distribution and complex roles necessitate further investigation.

Purpose of the Study:

• To conduct a bibliometric analysis of Transient Receptor Potential Vanilloid 1 (TRPV1) research.
• To visualize and identify key hotspots and emerging trends in TRPV1 channel studies.
• To map the evolution of research topics and collaborations in the TRPV1 field.

Main Methods:

• Bibliometric analysis of 9,113 TRPV1-related publications from inception to 2022, sourced from the Web of Science database.
• Utilized Excel, VOSviewer, and CiteSpace for co-authorship, co-citation, and co-occurrence analyses.
• Keyword clustering to identify prominent research themes and topic distributions.

Main Results:

• Publication output shows rapid growth post-1989, with a citation peak in 2000.
• The United States leads in publications, followed by Japan, China, and England.
• Recent research trends encompass inflammation, oxidative stress, apoptosis, neuralgia, and TRPV1 antagonists as therapeutic targets.

Conclusions:

• Bibliometric analysis reveals key research areas including neuralgia, the endogenous cannabinoid system, TRPV1-mediated airway hyperresponsiveness, apoptosis, and TRPV1 antagonists.
• The precise ion channel mechanism of TRPV1 requires further elucidation.
• In-depth basic research is crucial for a comprehensive understanding of TRPV1 function and therapeutic applications.