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Related Experiment Video

Updated: Aug 4, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

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Published on: September 3, 2013

Choline PET/CT in recurrent prostate cancer.

Beatrice Detti¹, Maria Grazia Carnevale², Sara Lucidi²

¹Radiation Oncology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Frontiers in Oncology

|April 7, 2023

Summary

Choline PET/CT accurately detects prostate cancer recurrence earlier than traditional methods. This imaging helps guide salvage treatments, improving outcomes for patients with biochemical recurrence after prostatectomy.

Keywords:

[18F]-choline PET/CT biochemical relapse metastasis-directed therapy prostate cancer stereotactic ablative radiotherapy stereotactic radiotherapy

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Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

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Published on: November 13, 2012

Area of Science:

Oncology
Nuclear Medicine
Radiology

Background:

Biochemical recurrence (BR) affects up to 40% of prostate cancer (PCa) patients post-radical prostatectomy (RP).
Early detection of recurrence is crucial for effective salvage therapy and improved patient outcomes.

Purpose of the Study:

To evaluate the diagnostic accuracy of choline PET/CT in detecting prostate cancer recurrence.
To assess the impact of choline PET/CT findings on subsequent treatment strategies and oncological outcomes in patients with biochemical recurrence.

Main Methods:

Analysis of data from 410 patients with non-metastatic prostate cancer (nmPCa) and biochemical recurrence (BR) after RP.
Choline PET/CT imaging was performed to identify sites of recurrence.
Multivariate analysis was used to identify prognostic factors for overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS).

Main Results:

Choline PET/CT was positive in 57.1% of patients, identifying recurrence sites.
Chemotherapy and PSA at recurrence were significant independent prognostic factors for OS.
Gleason score, number of relapse sites, and PSA levels were significant prognostic factors for DFS.

Conclusions:

Choline PET/CT offers superior accuracy compared to conventional imaging for assessing nmPCa with BR post-prostatectomy.
This imaging modality facilitates timely salvage strategies, potentially improving quality of life for patients.