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Updated: Aug 3, 2025

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SOCS3 as a potential driver of lung metastasis in colon cancer patients

Xuejie Li1, Zuyi Yang2, Bi Chen3,4

  • 1Department of Pathology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, China.

Frontiers in Immunology
|April 7, 2023
PubMed
Abstract

Insights

Suppressor of cytokine signaling 3 (SOCS3) is linked to poorer colon cancer prognosis and increased immune cell infiltration. High SOCS3 and CD163 expression in lung metastasis suggests a role in tumor progression and potential immunotherapy targets.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The JAK-STAT signaling pathway is crucial in cellular communication and is negatively regulated by suppressor of cytokine signaling 3 (SOCS3).
  • Understanding SOCS3's role in cancer, particularly its interplay with immune cells, is vital for developing effective treatments.

Purpose of the Study:

  • To investigate the expression patterns of SOCS3 in primary colon tumors and their lung metastases.
  • To explore the relationship between SOCS3 status and macrophage markers (CD68, CD163) in colon cancer patients.
  • To elucidate the molecular mechanisms of SOCS3 in lung metastasis using TCGA data.

Main Methods:

  • Utilized immunohistochemistry (IHC) to assess SOCS3, CD68, and CD163 expression in 32 colon cancer patient samples with lung metastasis.
  • Analyzed the correlation between SOCS3 expression and macrophage markers.
  • Employed TCGA database to investigate the molecular mechanisms of SOCS3 in lung metastasis.

Main Results:

  • Higher SOCS3 expression correlated with poorer prognosis and increased immune cell infiltration across various cancer types, notably colon cancer.
  • Lung metastases exhibited higher CD163 and SOCS3 expression compared to primary colon tumors.
  • Elevated SOCS3 expression in lung metastasis was associated with increased CD163 expression, suggesting a link with M2 macrophages.
  • Differentially expressed genes in lung metastasis were significantly enriched in immune response pathways.

Conclusions:

  • SOCS3 demonstrates potential as a prognostic biomarker in various cancers.
  • SOCS3 may serve as a therapeutic target for immunotherapeutic interventions, particularly in colon cancer.
  • Further research into SOCS3's role in tumor progression and immunotherapy is warranted for colon cancer treatment strategies.
Keywords:
SOCS3colon primary tumorimmune infiltrationlung metastasismacrophage

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