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The Role of Stereotactic Radiosurgery for Functioning and Nonfunctioning Pituitary Adenomas
Eric J Lehrer1, Roman O Kowalchuk2, Daniel M Trifiletti3
1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neurology India
|April 7, 2023
Summary
Stereotactic radiosurgery (SRS) effectively treats pituitary adenomas, achieving 80%-90% tumor control. Hypofractionated SRS offers an alternative for complex cases, though data remain limited.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Endocrinology
Background:
- Pituitary adenomas are common central nervous system neoplasms.
- Stereotactic radiosurgery (SRS) is an effective treatment for pituitary adenomas.
- Potential side effects of SRS include endocrine dysfunction and visual deficits.
Purpose of the Study:
- To review the efficacy and safety of SRS for pituitary adenomas.
- To explore hypofractionated SRS as an alternative for specific patient groups.
Main Methods:
- Comprehensive literature search of major databases (PubMed/MEDLINE, CINAHL, Embase, Cochrane Library).
- Identification and analysis of studies reporting SRS use in pituitary adenoma management.
Main Results:
- SRS demonstrates high tumor control rates (80%-90%) for pituitary adenomas.
- Permanent morbidity from SRS is infrequent.
- Hypofractionated SRS is a potential option for cases unsuitable for single-fraction SRS, but data are limited.
Conclusions:
- SRS is a valuable treatment for pituitary adenomas.
- Hypofractionated SRS requires further investigation for complex pituitary adenoma cases.
