Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

14.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.0K
Aging01:26

Aging

96
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
96
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
Regulation of Metabolism01:19

Regulation of Metabolism

9.6K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Outpatient Epidural Analgesia in Advanced Colorectal Adenocarcinoma: A Case Report.

Cureus·2026
Same author

Current progress in the use of pyrazole-containing compounds for neuroprotection as a strategy to counteract neurodegeneration.

Biochemical pharmacology·2026
Same author

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores.

Environmental microbiology·2026
Same author

Vibrational spectroscopy as a complementary approach to monitor SH-SY5Y cell differentiation.

Analytical biochemistry·2026
Same author

Improved drug delivery across the blood-brain barrier through post-insertion functionalization of lipid nanocapsules with cannabidiol using click chemistry.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Genomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health risks.

Veterinary research communications·2026

Related Experiment Video

Updated: Aug 3, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.6K

Metabolomics to Study Human Aging: A Review.

Claudia Martins1, Sandra Magalhães2, Idália Almeida1,3

  • 1Department of Medical Sciences, iBiMED: Institute of Biomedicine, University of Aveiro, Agra do Crasto, Aveiro 3810-193, Portugal.

Current Molecular Medicine
|April 7, 2023
PubMed
Summary

As people live longer, understanding aging is crucial. This review explores aging models and metabolomics biomarkers, highlighting senescence markers to aid aging research.

Keywords:
Aginganimal modelsbiomarkers of senescence.cellular modelsmetabolomicssenescence

More Related Videos

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

4.5K
Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

4.1K

Related Experiment Videos

Last Updated: Aug 3, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.6K
Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

4.5K
Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

4.1K

Area of Science:

  • Gerontology and Cellular Biology
  • Biomarker Discovery
  • Metabolomics

Background:

  • Increasing life expectancy presents significant social, health, and economic challenges.
  • Understanding the physiology of aging is essential to address these challenges.
  • Human aging studies are complex, necessitating the use of cellular and animal models.

Purpose of the Study:

  • To summarize various aging study models, detailing their advantages and limitations.
  • To review metabolomics-driven biomarker discovery in aging research.
  • To describe common senescence biomarkers and their significance.

Main Methods:

  • Literature review of aging models (cellular and animal).
  • Systematic search for published articles on metabolomics-based aging biomarkers.
  • Analysis and comparison of findings from different metabolomics studies.
  • Description of established senescence biomarkers.

Main Results:

  • Metabolomics offers a powerful approach for identifying aging biomarkers.
  • Diverse aging models provide valuable insights but have limitations.
  • Several senescence biomarkers are frequently identified and studied.
  • Comparative analysis reveals consistency and variability in metabolomics findings across studies.

Conclusions:

  • Metabolomics is a key tool for unraveling aging complexities and discovering biomarkers.
  • Appropriate selection of aging models is critical for research success.
  • Senescence biomarkers are vital for understanding aging mechanisms.
  • Further research integrating models and metabolomics is needed.