Related Experiment Video
Updated: Aug 3, 2025

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
The expression of Runx2 in the pathogenesis of periodontitis
Miaomiao Wang1,2, Chunjiao Xu1,3, Xiaoshan Wu4,5
1Department of Periodontology, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.
Objective:
Runt-related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis.
Methods:
Gingival samples of patients were collected, including healthy samples (control group) and periodontitis samples (P group). Periodontitis samples were divided into three groups based on the periodontitis stage. Samples with stage I and grade B periodontitis were in the P1 group, stage II and grade B in the P2 group, and stage III or IV and grade B in the P3 group. Immunohistochemistry and western blotting were performed to detect Runx2 levels. The probing (PD) and clinical attachment loss (CAL) were recorded.
Results:
Runx2 expression levels in the P and P3 groups were higher than those in the control group. In addition, Runx2 expression was positively correlated with CAL and PD (r1 = 0.435, r2 = 0.396).
Conclusion:
The high expression level of Runx2 in the gingiva of patients with periodontitis may be correlated with the pathogenesis of periodontitis.
Related Concept Videos
TGF - β Signaling Pathway
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
RNA Polymerase II Accessory Proteins
The JAK-STAT Signaling Pathway
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation

