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Related Experiment Video

Updated: Aug 3, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Normothermic Machine Perfusion Systems: Where Do We Go From Here?

Sara López-Martínez1, Carlos Simón1,2,3,4, Xavier Santamaria1,5

  • 1Carlos Simon Foundation, Centro de Investigación Príncipe Felipe, Valencia, Spain.

Transplantation
|April 7, 2023
PubMed
Summary

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Normothermic machine perfusion (NMP) preserves organs ex vivo by simulating body temperature. Advancements in NMP systems offer extended preservation times for transplantation and biomedical research.

Area of Science:

  • Organ transplantation and preservation
  • Biomedical engineering
  • Regenerative medicine

Background:

  • Normothermic machine perfusion (NMP) aims to maintain organs ex vivo under physiological conditions, specifically body temperature.
  • Clinical NMP systems are effective for liver, heart, lung, and kidney transplantation, preserving organs for up to 1 day.
  • Preclinical research has extended NMP preservation times up to one week through optimized circuit design, perfusate composition, and automated monitoring.

Approach:

  • This review synthesizes recent research on NMP systems.
  • It covers devices currently in clinical trials and innovative preclinical platforms.
  • The review also examines NMP applications for a wider range of organs and discusses global strategies.

Key Points:

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Related Experiment Videos

Last Updated: Aug 3, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Published on: May 26, 2015

11.7K
Normothermic Ex Vivo Liver Machine Perfusion in Mouse
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Normothermic Ex Vivo Liver Machine Perfusion in Mouse

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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

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  • NMP technology has advanced significantly, enabling longer organ preservation.
  • Emerging NMP platforms show promise for pancreas, intestine, uterus, ovary, and vascularized composite allografts.
  • NMP is poised to become a crucial tool in transplantation and a valuable asset for biomedical research.

    • Conclusions:

    • NMP offers a promising approach to ex vivo organ preservation.
    • Continued innovation in NMP systems is expanding its applicability and potential benefits.
    • NMP is expected to enhance organ transplantation success rates and advance research capabilities.