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MicroRNA expression in osteoarthritis: a meta-analysis
Huachen Liu1,2, Lei Yan1,2, Xiaoke Li1,2
1Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road No. 79, Hangzhou, China.
Clinical and Experimental Medicine
|April 7, 2023
Summary
MicroRNAs (miRNAs) play a crucial role in osteoarthritis (OA) progression. This review identified key miRNAs, including miR-146a-5p and miR-34a-5p, as potential diagnostic biomarkers for early osteoarthritis detection.
Area of Science:
- Biochemistry and Molecular Biology
- Genetics and Genomics
- Rheumatology and Orthopedics
Background:
- Osteoarthritis (OA) is a leading cause of global disability, necessitating improved diagnostic and therapeutic strategies.
- MicroRNAs (miRNAs) are increasingly recognized for their involvement in OA pathogenesis.
- Identifying reliable biomarkers is crucial for early OA diagnosis and management.
Conclusions:
- miRNA signaling is critically important in the progression of osteoarthritis.
- Specific miRNAs, including miR-146a-5p, miR-34a-5p, miR-127-5p, and miR-140-5p, are highlighted as promising biomarkers for OA.
- These identified miRNAs warrant further investigation for their diagnostic and potentially therapeutic applications in osteoarthritis.
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