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Oestrogens and bone metabolism: a hypothesis.

S A Duursma, J W Bijlsma, H C van Paassen

    Maturitas
    |March 1, 1986
    PubMed
    Summary

    Oestrogen replacement therapy in post-menopausal women may affect bone metabolism by altering growth hormone (GH) and somatomedin (insulin-like growth factor) levels, rather than solely calciotrophic hormones.

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    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Post-menopausal Health

    Background:

    • Traditional explanations for oestrogen's effects on bone metabolism focus on calciotrophic hormones.
    • Previous research indicates oestrogen therapy alters growth hormone (GH) and somatomedin levels in post-menopausal women.

    Purpose of the Study:

    • To propose a novel hypothesis for how oestrogen replacement therapy influences bone metabolism in post-menopausal women.
    • To investigate the role of somatomedin and GH in mediating oestrogen's effects on bone.

    Main Methods:

    • Analysis of previous study findings [6].
    • Review of relevant published literature on oestrogen, bone metabolism, somatomedin, and GH.
    • Formulation of a hypothesis based on integrated data.

    Main Results:

    • Oestrogen treatment in post-menopausal women was associated with decreased somatomedin concentrations.
    • Oestrogen treatment was also associated with increased growth hormone (GH) concentrations.

    Conclusions:

    • The study hypothesizes that changes in serum somatomedin and GH concentrations mediate the effects of oestrogen replacement therapy on bone metabolism in post-menopausal women.
    • This challenges the exclusive focus on calciotrophic hormones in explaining these effects.

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