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Related Experiment Video

Updated: Aug 3, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

A Needle-Free Transdermal Patch for Sampling Interstitial Fluid.

Daniel J O'Brien, Darrian Mills, Joseph Farina

IEEE Transactions on Bio-Medical Engineering

|April 7, 2023

Summary

This summary is machine-generated.

A novel skin patch painlessly samples dermal interstitial fluid using thermal poration, offering a less invasive diagnostic alternative. This technology bypasses the stratum corneum for efficient biomarker collection without needles.

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Area of Science:

Biomedical Engineering
Materials Science
Dermal Diagnostics

Background:

Current diagnostics often rely on invasive blood or urine sampling.
Accessing dermal interstitial fluid is challenging due to the stratum corneum barrier.
Minimally invasive methods for interstitial fluid collection are highly desirable.

Purpose of the Study:

To develop and evaluate a novel, minimally invasive patch for sampling dermal interstitial fluid.
To overcome the barrier of the stratum corneum without needle-based technology.
To enable efficient fluid collection for biomarker quantification.

Main Methods:

Development of a flexible, Band-Aid-like patch with integrated resistive heating elements.
Utilizing thermal poration to create temporary pathways through the stratum corneum.
Employing self-driving hydrophilic microfluidic channels for fluid transport to an on-patch reservoir.

Main Results:

Successful rapid collection of sufficient interstitial fluid from ex-vivo human skin models.
Finite-element modeling confirmed stratum corneum poration without inducing pain.
The patch demonstrated a higher collection rate compared to microneedle-based alternatives.

Conclusions:

The developed patch offers a painless, needle-free method for sampling human bodily fluids.
The technology utilizes simple, scalable fabrication methods.
This innovation holds significant potential for clinical applications and integrated on-patch testing.