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A Needle-Free Transdermal Patch for Sampling Interstitial Fluid.

Daniel J O'Brien, Darrian Mills, Joseph Farina

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    |April 7, 2023
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    Summary
    This summary is machine-generated.

    A novel skin patch painlessly samples dermal interstitial fluid using thermal poration, offering a less invasive diagnostic alternative. This technology bypasses the stratum corneum for efficient biomarker collection without needles.

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    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Dermal Diagnostics

    Background:

    • Current diagnostics often rely on invasive blood or urine sampling.
    • Accessing dermal interstitial fluid is challenging due to the stratum corneum barrier.
    • Minimally invasive methods for interstitial fluid collection are highly desirable.

    Purpose of the Study:

    • To develop and evaluate a novel, minimally invasive patch for sampling dermal interstitial fluid.
    • To overcome the barrier of the stratum corneum without needle-based technology.
    • To enable efficient fluid collection for biomarker quantification.

    Main Methods:

    • Development of a flexible, Band-Aid-like patch with integrated resistive heating elements.
    • Utilizing thermal poration to create temporary pathways through the stratum corneum.
    • Employing self-driving hydrophilic microfluidic channels for fluid transport to an on-patch reservoir.

    Main Results:

    • Successful rapid collection of sufficient interstitial fluid from ex-vivo human skin models.
    • Finite-element modeling confirmed stratum corneum poration without inducing pain.
    • The patch demonstrated a higher collection rate compared to microneedle-based alternatives.

    Conclusions:

    • The developed patch offers a painless, needle-free method for sampling human bodily fluids.
    • The technology utilizes simple, scalable fabrication methods.
    • This innovation holds significant potential for clinical applications and integrated on-patch testing.