Related Experiment Video

Updated: Aug 3, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

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How common is hypertrophic cardiomyopathy… really?: Disease prevalence revisited 27 years after CARDIA

Daniele Massera1, Mark V Sherrid1, Martin S Maron2

  • 1Hypertrophic Cardiomyopathy Program, Leon H. Charney Division of Cardiology, NYU Langone Health, New York, NY, United States of America.

International Journal of Cardiology
|April 7, 2023
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people, is a treatable heart condition, and is likely underdiagnosed. This cardiac disease can lead to serious complications if not identified and managed.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac disease characterized by left ventricular hypertrophy.
  • It affects all ages and races, with potential for heart failure, atrial fibrillation, and sudden death.

Purpose of the Study:

  • To estimate the prevalence of hypertrophic cardiomyopathy in the general population.
  • To assess the clinical relevance of current prevalence estimates for diagnosis and management.

Main Methods:

  • Systematic review of studies estimating HCM prevalence.
  • Analysis of echocardiography, cardiac magnetic resonance imaging (CMR), and electronic health records.
  • Inclusion of data from population-based studies like CARDIA and UK Biobank.

Main Results:

  • The estimated prevalence of HCM based on left ventricular hypertrophy is 1:500 (0.2%) in the general population.
  • This prevalence has been consistently reported across multiple studies and imaging modalities.
  • HCM is not a rare condition, potentially affecting millions worldwide.

Conclusions:

  • The 1:500 prevalence is clinically relevant for assessing and managing HCM.
  • HCM is likely underdiagnosed, highlighting the need for increased clinical awareness and diagnostic efforts.
  • Current data suggest a significant global burden of HCM, impacting approximately 15 million individuals worldwide.

Keywords:
EpidemiologyHypertrophic cardiomyopathyPrevalence

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