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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

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[Hospitalization for infection in patients treated for giant cell arteritis: A single-centre retrospective study]

P Lavrard-Meyer1, Q Gomes De Pinho1, A Daumas2

  • 1Assistance Publique des hôpitaux de Marseille (APHM), hôpital Nord, service de médecine interne, Aix-Marseille Université (AMU), Marseille, France.

La Revue De Medecine Interne
|April 7, 2023
PubMed

Insights

Infections increase mortality in giant cell arteritis (GCA) patients. This study identified risk factors for infection and found seritis was more common in infected patients, while GCA relapses were less frequent.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Infections are a significant cause of morbidity and mortality in patients with giant cell arteritis (GCA).
  • Understanding factors contributing to infection risk is crucial for managing GCA patients.
  • Previous studies highlight the association between GCA and increased susceptibility to infections.

Purpose of the Study:

  • To identify factors predisposing to infection risk in GCA patients.
  • To describe characteristics of GCA patients hospitalized with infections during treatment.
  • To analyze the clinical presentation and outcomes of infections in GCA.

Main Methods:

  • A monocentric retrospective study compared GCA patients hospitalized for infection (cases) with matched controls (no infection).
  • The study included 21 patients with 26 infections and 42 control patients.
  • Matching criteria included sex, age, and GCA diagnosis.

Main Results:

  • Patients with infections showed a higher frequency of seritis (15% vs. 0%, p=0.03) compared to controls.
  • GCA relapses were less frequent in patients with infections (23.8% vs. 50.0%, p=0.041).
  • Hypogammaglobulinemia was observed during infection; over half of infections occurred within the first year of treatment with average 15mg/day corticosteroids. Pulmonary (46.2%) and cutaneous (26.9%) infections were most common.

Conclusions:

  • Key factors associated with infectious risk in GCA patients were identified.
  • This preliminary study underscores the need for further investigation into infection management in GCA.
  • Findings will inform a larger, national multicenter study on GCA-associated infections.
Abstract

Keywords:
Artérite à cellules géantesCorticoïdesGiant cell arteritisGlucocorticoidsHorton's DiseaseInfectionsMaladie de HortonVasculariteVasculitis

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