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Updated: Aug 3, 2025
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
Retinal microvasculature in schizophrenia: A meta-analysis with trial sequential analysis of studies assessing vessel
Siddharam S Janti1, Sai Krishna Tikka2
1Department of Ophthalmology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India.
Abstract:
We performed a series of random-effects meta-analyses on cross-sectional studies assessing vessel density (VD) using Optical Coherence Tomography Angiography (OCTA) in schizophrenia. Five studies with a total sample size of 410 (schizophrenia-192;healthy-218) were analysed. Supplementary Trial Sequential Analyses (TSA) was also performed. Meta-analyses revealed significantly lower VD in schizophrenia patients compared to healthy controls in the peripapillary region of the optic disc, including both superior hemisphere and inferior hemisphere. TSA validated these significant effects. We conclude that reduced VD at the peripapillary region of the optic disc as measured by OCTA may have the potential to be a schizophrenia biomarker.
